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  • Article

The side effects of lithium mining

Laura Grace Simpkins attempts to untangle some uncomfortable truths about the social and environmental costs of making her medication.

  • Long read

Primodos, paternalism and the fight to be heard

Journalist Florence Wildblood examines the case of Primodos – a conveniently quick but risky hormone pregnancy test that was prescribed in the 1960s and ’70s – and profiles two women at the story’s shocking heart.

  • Article

Dating on dopamine

Drug treatment for Parkinson’s can come with an unwanted side serving of compulsive behaviour, as Pete Langman discovered. Read about his dating journey in a dopamine cloud.

  • Article

Chemical highs and psychedelic research

Could recreational drugs make you happy? Kate Wilkinson explores why keen clubber Simon believes taking psychedelics has helped him develop as a person.

All stories (18)

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  • Solanum laciniatum Aiton Solanaceae. Kangaroo Apple. Evergreen shrub. Distribution: New Zealand and the east coast of Australia. It contains steroidal saponins that can be converted into steroids, including progesterone, oestrogens, cortisone, prednisolone etc. In 1943, Professor Russell Marker discovered a method of obtaining an unsaturated steroidal saponine, diosogenin, from Mexican yam (Dioscorea mexicana), which can easily and cheaply be converted into steroids, such as prednisone and progesterone, reducing the price of steroid production to a fraction (0.5%) of its former cost. For 20 years drug companies showed little interest, and it was only as a result of Professor Marker forming his own company, and the concerted efforts of several gynaecologists, physiologists and birth-control advocates, that the contraceptive pill was ‘born’ in 1960. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Taxus baccata L. Taxaceae European Yew. Trees are feminine in Latin, so while Taxus has a masculine ending (-us), its specific name, baccata (meaning 'having fleshy berries' (Stearn, 1994)), agrees with it in gender by having a female ending ( -a). Distribution: Europe. Although regarded as poisonous since Theophrastus, Gerard and his school friends used to eat the red berries (they are technically called 'arils') without harm. Johnson clearly ate the fleshy arils and spat out the seed, which is as poisonous as the leaves. It is a source of taxol, an important chemotherapeutic agent for breast and other cancers. It was first extracted from the bark of T. brevifolia, the Pacific yew tree, in 1966. About 1,100 kg of bark produces 10 g of taxol, and 360,000 trees a year would have been required for the needs of the USA – an unsustainable amount. In 1990 a precursor of taxol was extracted from the needles of the European yew so saving the Pacific trees. It is now produced in fermentation tanks from cell cultures of Taxus. Curiously, there is a fungus, Nodulisporium sylviforme, which lives on the yew tree, that also produces taxol. Because taxol stops cell division, it is also used in the stents that are inserted to keep coronary arteries open. Here it inhibits – in a different way, but like anti-fouling paint on the bottom of ships – the overgrowth of endothelial cells that would otherwise eventually block the tube. The economic costs of anticancer drugs are significant. Paclitaxel ‘Taxol’ for breast cancer costs (2012) £246 every 3 weeks
  • Brain Organoid.
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